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Human Equivalent Dose: Understanding Drug Dosing in Clinical Trials- Drug dosing is a critical aspect of clinical trials, as it directly affects the safety and efficacy of the drug being tested. However, determining the appropriate dose for a drug can be a complex process, particularly when translating results from animal studies to humans.  To address this issue, researchers often use the concept of human equivalent dose (HED) to help estimate a safe and effective dosage range for human subjects. In this article, we will explore what HED is, how it is calculated, and its importance in drug development. What is Human Equivalent Dose? Human equivalent dose is a mathematical calculation used to convert animal doses to human doses. This calculation takes into account the differences in body size and physiology between animals and humans. The HED is an estimation of the equivalent dose that would be required to achieve similar effects in humans as observed in animals. Calculating HED The c